فاکتورهای موثر بر پیشآگهی بیماری پمفیگوس ولگاریس: مطالعه روی 119 بیمار
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Abstract:
Background: Since the systemic steroids are introduced in Pemphigus Vulgaris treatment, the prognosis of disease improved significantly. This study was designed to evaluate determining factors in the prognosis of pemphigus vulgaris in Iranian patients. Methods: In this study, 119 patients with documented pemphigus vulgaris who had presented to Razi Hospital from 2001 until 2003 were included. These patients had presented for the first time and treated with prednisolone and Azathioprine. Morality rate, minor and major relapses and duration of first remission had been defined as prognostic criteria and correlation between them and other demographic variables and disease characteristics were investigated. Results: The majority of patients (84.1%) were followed for more than one year. The major recurrence and minor recurrence occurred in 28(23.5%) and 65(54.6%) of patients respectively, no case of mortality was observed. In patients who received treatment six months or less after onset of disease the frequency of major recurrence was less than the others. 18(17.8%) vs. 12(41.4%), (p=0.009). Duration of primary remission more than one year was detected in most of the patients (64.7%). In patients with less than 10 initial cutaneous lesions, period of primary remission was longer than the other patients. (p=0.009). Shorter duration of primary remission were noted in older patients (age>50) in comparison with younger patients (age≤50, p=0.04). Conclusions: Male gender, old age, interval more than 6 months between onsets of symptoms to initial treatment and more than 10 skin lesions on admission, are associated with poor prognosis of pemphigus vulgaris.
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رابطه گروه خون وRH با بروز بیماری پمفیگوس ولگاریس
One hundred patients were studied and 93 of them suffered from Pemphigus Vulgaris and 7 of them were suffered from Pemphigus Foliaceus. The results were compared with control group. Results : There is not relationship between blood group and Pemphigus, but incidence of Pemphigus in Rh+ patients is more than Rh- patients.
full textدرمان هومیوپاتی و بیماری پمفیگوس ولگاریس: گزارش چند مورد
درمان هومیوپاتی و بیماری پمفیگوس ولگاریس: گزارش چند مورد دکتر امیرمنصور شیرانی*- دکتر فهیمه موسوی** *- استادیار گروه آموزشی بیماریهای دهان و تشخیص دانشکده دندانپزشکی دانشگاه علوم پزشکی اصفهان. **- دانشیار گروه آموزشی بیماریهای دهان و تشخیص دانشکده و عضو مرکز تحقیقات دندانپزشکی دانشگاه علوم پزشکی تهران. چکیده زمینه و هدف: پمفیگوس ولگاریس یک بیماری زخمی تاولی و اتوایمیون مزمن است که پوست و مخاط ر...
full textگزارش یک مورد بیماری پمفیگوس ولگاریس با تظاهرات بالینی شبیه آبله مرغان
بیماری پمفیگوس ولگاریس یک بیماری اتوایمیون بالقوه کشنده است که به شکل تاولهای بزرگ و منتشر در سراسر بدن بروز میکند و اگر درمان نشود، اکثر بیماران در عرض پنج سال فوت می کنند. این بیماری معمولا در دهه پنجم و ششم زندگی بروز می کند. در اینجا ما دختر هفده ساله ای را گزارش می کنیم که دچار پمفیگوس شده است، ولی تظاهرات بالینی آن شبیه به بیماری آبله مرغان بود. از آنجا که پمفیگوس ولگاریس در موارد خیلی...
full textسطح سرمی آنتیاکسیدانها در بیماران مبتلا به پمفیگوس ولگاریس
Background & Aims: Pemphigus comprises a group of autoimmune life threading diseases characterized by cutaneous and mucosal blistering. Pemphigus vulgaris (PV) is the most common and important variant. Recent reports have revealed the relatively high incidence of PV in Iran. The onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of ...
full textپمفیگوس ولگاریس لثه ای در بیماران جوان:گزارش موارد
Pemphigus vulgaris is an autoimmune and rare mucocutaneous disease with outbreak of 1 to 5 patients per 1 million people. The average age at onset of disease is usually 50 years. In this study four young females (mean age: 27.75 years) with pemphigus vulgaris are presented. The first patient was a 28-year-old female complaining from various oral sores. She was diagnosed with pemphigus vulgar...
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Journal title
volume 66 issue None
pages 913- 918
publication date 2009-03
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